Arda Turan and Rafael Alcantara have come in for Luis Enrique's side, while Aleix Vidal receives a rare chance to impress from the start
Luis Enrique has opted to leave Neymar, Andres Iniesta and Ivan Rakitic on the bench for Barcelona against Las Palmas as he reshuffles his pack.
The La Liga champions host the Canary Islanders hoping to temporarily close the gap at the top of the table to two points with Real Madrid, who face Sevilla on Sunday.
Las Palmas are punching above their weight and currently sit eighth, though Enrique seems undeterred as he hands his bit-part players some game time.
Aleix Vidal receives his second league start for just the second time since last October, completing the backline alongside Samuel Umtiti who replaces Gerard Pique - omitted from the squad altogether.
Andre Gomes and Rafael Alcantara flank Sergio Busquets and support an attacking triumvirate consisting of Lionel Messi, Luis Suarez and Arda Turan.
Messi will be seeking a career-first La Liga goal against Las Palmas, who can call on Kevin-Prince Boateng - the midfielder scoring twice in six appearances against Barcelona while with AC Milan - in the centre of the park.
Barcelona XI: Ter Stegen; Vidal, Mascherano, Umtiti, Alba; Gomes, Busquets, Rafael; Messi, Suarez, Arda
Subs: Rakitic, Cillessen, Digne, Neymar, Iniesta, Alcacer, Mathieu
Las Palmas XI: Varas, Macedo, Lemos, Garcia, Oliveira Lopes; Viera, Mesa, Gomez; Boateng; El Zhar, Dominguez
Subs: Lizoain, Montoro, Artiles, Momo, Simon, Livaja, Garcia